Subcutaneous Transmitter

System Description

Subcutaneous Transmitters: Detailed description and set-up instructions.
Publications: List of published papers describing studies done with the telemetry system.
Example Recordings: A selection of recordings made with our subcutaneous transmitters.
Parts and Prices: A list of devices and their prices in various quantities.
Testimonials: Comments from users of our telemetry system.
News Group: Private news group for discussion of implantation and analysis.

Circuit Manuals

Subcutaneous Transmitter (A3028): Single or dual channel EEG, ECG or EMG monitor.
Antenna (A3015C): Antennas with coaxial socket for receiving telemetry signals.
Faraday Enclosure: Faraday enclosures to block ambient interference.
Faraday Enclosure Feedthrough (A3039): Coaxial and ethernet feedthroughs for Faraday enclosures.
Octal Data Receiver (A3027): Message receiver with eight independent antenna inputs.
LWDAQ Driver (A2071E): A TPCIP server and power supply for data acquisition.
Animal Location Tracker (A3038): Combined message receiver, location tracker and TCPIP server.
Battery Charger (A3033): Battery rhargers for rechargeable trabnsmitters.

Software Guides

LWDAQ Software: Data acquisition software, communicates with hardware over TCPIP.
Receiver Instrument: The software instrument that downloads telemetry data.
Neuroarchiver Tool: The software tool that records and processes telemetry data.

Application Notes

The Source of EEG: The origin of the EEG signal we record with our SCT electrodes.
Event Detection: Automatic detection of seizures, spikes, waves, and ripples.
Flexible Wires: Design and selection of leads and antennas for implants.
Electrodes: Design and selection of terminations of leads.
Reception: Measurements of radio-frequency reception reliability.
Mains Hum: The origin of the 50-Hz and 60-Hz noise we observe in laboratories.

Publications

Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures (Nov 2021) Kreye et al, J Exp Med, doi: 10.1038/s42003-021-02635-8.
Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody- mediated encephalitis (Sep 2021) Wright et al, Commun Biol, doi: 10.1038/s42003-021-02635-8.
Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation (Mar 2021) Gonzalez-Sulzer et al, Brain, doi.10.1093/brain/awab051.
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects (Nov 2020) Broekaart et al, J Clin Invest, doi: 10.1172/JCI138332.
Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome (Jan 2020) Chang et al, Cell Rep, doi: 10.1016/j.celrep.2019.12.065.
Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy (Sep 2019) Shekh-Ahmad et al, Redox Biol, doi: 10.1016/j.redox.2019.101278.
Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression (Jun 2019) Costart et al, Brain Stimul, doi: 10.1016/j.brs.2019.06.009.
Epilepsy Gene Therapy Using an Engineered Potassium Channel (Feb 2019) Snowball et al, J Neurosci, doi: 10.1523/JNEUROSCI.1143-18.2019.
Semiology, clustering, periodicity and natural history of seizures in an experimental visual cortical epilepsy model (Nov 2018) Chang et al, Dis Model Mech, doi: 10.1242/dmm.036194.
Biochemical autoregulatory gene therapy for focal epilepsy (Jul 2018) Leib et al, Nat Med, doi: 10.1038/s41591-018-0103-x.
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy (May 2018) Shekh-Ahmad et al, Brain, doi: 10.1093/brain/awy071.
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease (Apr 2018) Brown et al, eNeuro, doi: 10.1523/ENEURO.0426-17.2018.
A microRNA-129-5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses (May 2017) Rajman et al, EMBO, doi: 10.15252/embj.201695748.
Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline (Jan 2017) Khalil et al, Epilepsia, doi: 10.1111/epi.13645.
The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups (Oct 2016) Chang et al, Cereb Cortex, doi: 10.1093/cercor/bhw330.
Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model (Aug 2015) Wright et al, Brain, doi: 10.1093/brain/awv257.
Chemical-genetic attenuation of focal neocortical seizures (Apr 2014) Kaetzel et al, Nat Commun, doi: 10.1038/ncomms.4847.
Ceftriaxone Treatment after Traumatic Brain Injury Restores Expression of the Glutamate Transporter, GLT-1, Reduces Regional Gliosis, and Reduces Post-Traumatic Seizures in the Rat (Aug 2013) Goodrich et al, J Neurotrauma, doi: 10.1089/neu.2012.2712.
Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy (Nov 2012) Wykes et al, Sci Transl Med, doi: 10.1126/scitranslmed.3004190.
A Novel Telemetry System for Recording EEG in Small Animals: description of the subcutaneous transmitter system (Sep 2011) Chang et al, J Neurosci Methods, doi: 10.1016/j.jneumeth.2011.07.018.